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LDH-based sensing detects the electrochemical oxidation of NADH generated when lactate is enzymatically converted to pyruvate

10.1093/pcp/pcr133 2 AstierJ.KulikA.KoenE.Besson-BardA.BourqueS.JeandrozS.et al

Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1/VEGF signaling pathway in experimental stroke

However, blockade of inward rectifying K-channels (K ir ) depolarizes the neuron, prolongs depolarization, and leads to either epileptiform activity or cellular death (see Figure 3)