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Cellular and molecular mechanisms in IPF Research on the pathogenesis of IPF has focused on chronic inflammation [61], abnormal wound healing [62], and models combining multifactorial and heterogeneous disease processes, such as cellular senescence, oxidative stress, endoplasmic reticulum stress, cellular plasticity, and the role of non-coding RNAs

Studies have linked shift work to increased cardiovascular disease risk, particularly among long-term shift workers, as it contributes to hypertension, dyslipidemia, metabolic syndrome, and impaired glucose metabolism, elevating the risks of cardiovascular disease and type 2 diabetes (175177)

A Dionex UltiMate 3000 506 LC System (Thermo Scientific) and a Q Exactive Orbitrap mass spectrometer (Thermo Scientific) operated in negative mode was used for targeted measurement