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Role of HDACs in epilepsy Although the pathogenesis of epilepsy has not been fully established, excitotoxicity, oxidative stress and neuroinflammation are regarded as the triads of epileptogenesis, a process during which triggers of brain insults such as status epilepticus by chemoconvulsants, infection or cerebrovascular disease include and the brain undergoes a cascade of morphological and functional changes prior to the onset of spontaneous recurrent seizures in chronic epilepsy [98], and epilepsy-associated neurodegeneration

Similarly, additional research showed that zero-valent iron nanoparticles transformed Fe(II) to enhance the Fenton reaction, resulting in mitochondrial lipid peroxidation in oral cancer cells (Huang K

Pediatr Neurol (2022) 126:3542

He et al., 2018) or various types of cells (Zhou et al., 2018b,c)