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Structure and mechanogating mechanism of the Piezo1 channel

Numerous studies have reported positive correlations between the levels of oxidative damage markers and clinical symptoms, such as joint swelling, morning stiffness duration, and pain scores

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JC1 detection of cell mitochondrial membrane potential Mitochondrial membrane potential was detected using a fluorescent dye mitochondrial membrane potential detection kit (JC-1) staining kit (Beyotime, Shanghai, China) ( 4 /well, and the cells were cultured according to the experimental method in Sections Cell culture and A 2535 insult, drug treatment, and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay. Subsequent experimental operations were carried out in strict accordance with the kit instructions