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Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

When cells are stimulated by apoptotic signaling, Bcl2-associated X protein (Bax) induces the permeabilization of the outer mitochondrial membrane, activating the initiator Caspase-9 and effector Caspase-3, thereby leading to apoptosis [17, 18]

Apr 2015;29(4):645-8

5 Mitochondrial metabolism, inflammatory tone and insulin resistance As mentioned above, LAC is an endogenous compound essential for -oxidation and is an emerging epigenetic modulator of glutamatergic function