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While glyoxalase II substrate S-D-lactoylglutathione (SLG) acts as a precursor of the D-lactyl moiety for non-enzymatic D-lactylation, highlighting the multifaceted characteristics of lactylation as a biological regulatory system consisting of substrate specificity, lactate source, and enzyme dependence

Since senescent cells may release a senescence-associated secretory phenotype, the authors suggest that lowering the senescent cell burden may reduce pro-fibrotic signaling in the surrounding cells

In particular, iCCA shows high rates of targetable genomic alterations, including IDH1/2 mutations (1320%) and FGFR2 fusion/rearrangements (1114%) (Fig

J Clin Exp Dent 2019;11:e12632