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While the evidence is still not enough to warrant the clinical use of sildenafil (or any other PDE5i) for the treatment of diabetic heart kinetics or as a first-line treatment for other CV complications in such patients, this new avenue of research looks promising, and new trials will hopefully allow the drafting of guidelines for clinical practice

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Effect of combination therapy with thyroxine (T4) and 3,5,3-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study