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High levels of peripheral pro-inflammatory cytokines compromise the BBB integrity, cross over to the brain vicinity, and activate its resident immune cells, causing microglial activation, which in turn creates a medium of neuroinflammation [297]

Statin-induced liver injury involves cross-talk between cholesterol and selenoprotein biosynthetic pathways

Moving release farther down the intestinal tract changes the pH, enzymes, transit conditions, mucus layer, surface area, and local concentration around the formulation

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