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Skin Lightening & Brightening Glutathione directly influences melanin production by inhibiting tyrosinase, it reduces melanin synthesis and produces a skin lightening and brightening effect

Inhibition of cell growth and induction of apoptosis by piperlongumine were also reported in human melanoma cells, via ROS-mediated mitochondria disruption and JNK (p-Jun N-terminal kinase) pathway [90]

Similarly, in hepatocytes exposed to lipotoxic stressors, zinc supplementation reduces cytotoxicity by mitigating ER stress and enhancing antioxidant defense, demonstrating its capacity to preserve proteostasis and limit inflammatory responses 178

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