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G.ShermanP

Potentially modifiable comorbidity-related and treatment-related factors include diabetes mellitus (2 increase), smoking, alcohol and substance abuse, exposure to antipsychotic drugs with higher D2 blockade effect, higher cumulative and current dose or antipsychotic plasma levels, antipsychotic drug holidays (periods where the antipsychotic therapy is held), anticholinergic exposure, and acute drug-induced movement disorders such as parkinsonism and akathisia [37, 56]

When alcohol is metabolised, it increases oxidative stress and rapidly depletes glutathione stores in the liver

Nihal Altan-Bonnet et al