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98 GhoshSBhowmikSMajumdarSGoswamiAChakrabortyJGuptaSet al

Additionally, the endogenous administration of BDNF was shown to protect neurons within the substantia nigra from 6-OHDA and MPTP toxicity, both in rat and primate Parkinson models [31]

A deep understanding of the pathogenic mechanisms of PD is of crucial importance for overcoming the limitations of current single-target therapies and for developing synergistic treatment strategies capable of simultaneously intervening at multiple key nodes (Fig