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Declines in the reduced glutathione/oxidized glutathione ratio indicate compromised redox buffering capacity and heightened vulnerability to mitochondrial injury ( Neuromuscular biomarkers also undergo predictable declines

[57] It is highly expressed in the cerebral cortex, especially in layer V pyramidal neurons and certain interneurons, where it modulates thalamocortical information processing and may influence gamma oscillations, which are important for sensory integration and perception