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Recent researches have elucidated that the pathogenesis of CRC involves the dysregulation of a number of cascading signaling pathways, including signal transducer and activator of transcription 3 (STAT3), transforming growth factor- (TGF-), phosphoinositide 3-kinase/protein kinase (PI3K/Akt) and Wnt/-catenin, characterized by aberrant silencing or activation of specific targets (6)

However, it is best not to rely on over-the-counter medication for long periods

[DOI] [Google Scholar] 154.Rabai G., Orban M., Epstein I.R

More studies are still needed to define the normal metabolome and establish what constitutes normal intra- and inter-individual variability