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Although the enzymes necessary for glycolysis are found throughout the lens (see Cheng and Chylack116 for review), the first enzyme of the glycolytic pathway, hexokinase, which catalyzes the conversion of glucose to glucose-6-phosphate, is present at very low levels.117 The low level of hexokinase appears to be the rate-limiting factor for lens glucose metabolism and, therefore, restricts the generation of glucose-6-phosphate for both glycolysis and the hexose monophosphate shunt pathway118 (see later discussion)

doi: 10.1080/21655979.2021.1964158 229 XiaoXXuYMoschettaGAYuYFisherALAlfaro-MagallanesVMet al

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It is especially critical in tissues with high oxidative stress