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10.1161/01.CIR.0000109496.82683.49 Circulation 165 ShimamuraM.SatoN.WaguriS.UchiyamaY.HayashiT.IidaH.et al (2006)

All these findings have been confirmed in animal studies

During later days of growth, the concentration-dependent inhibitory effect of Cr and Cd ions was clearly visible

The MHRA Drug Safety Update on metformin and reduced vitamin B12 levels advises that B12 testing should be considered in patients who are symptomatic or who have risk factors for deficiency