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As we have discussed in prior rulemaking, when determining a new technology add-on payment, we provide payment based on the cost of the actual technology (such as the drug or device itself) and not for additional costs related to the use of the device (86 FR 45146)

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Recessive Mitochondrial syndromes: Adult onset CNS Parkinsonism NADH Dehydrogenase, Subunit 1 Alzheimer's/Parkinsonism Leber hereditary optic neuropathy mtRNA Lys (MTTK) : A8344G Parkinson syndrome, Neuropathy & Myopathy 66 mtRNA Thr (MTTT) LHON (G15927A): Variant also described in 1 family with coronary heart disease Occasional sporadic Parkinsonism mtRNA Pro (MTTP) 207 Occasional sporadic Parkinsonism : T15965C mtRNA Pro mutations: Other Myopathy Genetics Mutations may be restricted to muscle C15975T: PEO

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