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Summary Keywords astrocytes, blood-brain barrier, inflammation, neurodegeneration, Parkinsons disease, vasculature Citation Stoll AC and Harms AS (2026) Interconnected roles of astrocytes and the bloodbrain barrier in Parkinsons disease: pathological evidence, mechanistic insights, and knowledge gaps

The defining histopathological feature is suprabasilar clefting with only a single layer of rounded basal cells remaining (tombstones) and acantholysis (31)

This is a slow, unavoidable process that contributes to the softening of lines over a lifetime

It's also used in oral care products where it reduces the bitterness of other ingredients