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Finally, to assess a functional indicator of oxidative damage and mitochondrial reactive oxygen species production, the activity of aconitase, a redox-sensitive enzyme in the tricarboxylic acid cycle, was measured

Short-chain fatty acids: key antiviral mediators of gut microbiota

PLS-DA, partial least-squares discriminant analysis

While the most toxic antiretroviral drugs (e.g., Efavirenz) are slowly being taken out of the market, more research is still needed to fully discriminate ART toxicity and its contribution to comorbidities observed in HIV-positive patients, especially in the context of aging, which alters both drug kinetics and susceptibility of the host to ART-induced side effects