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Although the disease was stable in all patients, some of them showed remissions during treatment, but a correlation in remission occurrence and treatment were not clear.[] Also, other studies revealed no significant results due to controversial antioxidants active doses,[] whereas other reports evaluated antioxidant efficiency during remission and observed that SOD activity signiflcantly increased, but GPx activity was reduced after antioxidant treatment.[] In addition, there are some studies that were not able to report any significant differences between placebo treatment and antioxidant treatment due to closely similar clinical results.[] Furthermore, all clinical trials used far smaller medium potency antioxidants doses, a fact that again questions their effectiveness in chronic disease, such as IBD

Development of clinical guidelines for inborn errors of metabolism: commentary

Biomarker changes do not establish broad clinical benefits

The mineralization procedure was as follows: the time required to reach 200C (15 minutes), followed by the time to maintain the temperature at 200C (20 minutes)