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Buffers containing strong chelators (EDTA, EGTA) or reducing agents (DTT, -mercaptoethanol, TCEP) should be avoided at the reconstitution step, since chelators can strip copper from the GHK-Cu component

J Transl Med (2012) 10:88

The high-purity raw collagen, vacuum evaporation process achieving high collagen content, increased chemical-crosslinker-to-collagen ratio and optimized photochemical crosslinking, along with other key biomaterial properties, significantly differentiates the BPCDX from previous materials tested in humans (see Supplementary Table 1 for a detailed comparison)

It is associated with symptoms such as fatigue, light sensitivity, irritability, and sometimes depression