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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

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In particular, since both Eb- and Ec-domains lacked N-glycosylation sites, the production of proIGF-1Eb and proIGF-1Ec was unaffected by inhibition of N-glycosylation (Figs 7A and S8C)

Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion