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This response was significantly different from the background response which was obtained by applying Glu in the presence of glutamate receptor blockers, namely, AP5 25 M, a broad-spectrum NMDAr antagonist, DNQX 10 M, a non-NMDA receptor antagonist, and MPEP 10 M, a type 5 metabotropic glutamate receptor antagonist

FIGURE 1 2.3.1 Release of inflammatory mediators and increased oxidative stress In the initial stages of periodontitis, bacterial metabolic products in dental plaque motivate host cells, resulting into the unleashing of various inflammatory mediators