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Interestingly, we did not observe any significant variations in MMA concentration in non-CNS tissues of adult male and female Tbx1 +/ mice (Fig S2), indicating that this phenotype is brain-specific

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Ethics statement The studies involving humans were approved by the National Center for Health Statistics Institutional Review Board ( The studies were conducted in accordance with the local legislation and institutional requirements

Thus, maintenance of CD38 expression is likely important for continued responsiveness of MM cells to anti-CD38 therapy