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However, for probiotic therapies to be truly integrated into clinical practice, three practical challenges must still be addressed: verification of long-term safety, optimization of cost-effectiveness, and assurance of patient compliance

It is found in nearly every cell in the body, but it is most concentrated in the liver

Shi ZZ, Osei-Frimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW: Glutathione synthesis is essential for mouse development but not for cell growth in culture

This issue is further intensified by mitochondrial dysfunction, which impairs energy production and increases the creation of ROS