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elegans and mice showed that EGCG's transient inhibition of Complex I in the electron transport chain triggered an adaptive stress response (mitohormesis) that ultimately restored ATP levels, reduced reactive oxygen species below baseline, and significantly extended lifespan and physical fitness

Finding the answers to these questions will open up broader prospects for the research on the mechanism of cuproptosis and its clinical applications

Enzymes supporting phase 2 detoxification reactions, such as those involved in the biosynthesis of glutathione (e.g., -glutamylcysteine synthetase or GCS) and its conjugation to substrates (e.g., glutathione S -transferases or GSTs), are rapidly induced following exposure to stressful stimuli

PMID: 38452838 Cancer Cell Int ROR inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity