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Many insurance companies consider treatment of hyperhidrosis with iontophoresis or onabotulinumtoxin A medically necessary ONLY when topical aluminum chloride or other extra strength anti-perspirants are ineffective or result in a severe rash

Desplantez T, Verma V, Leybaert L, Evans WH, Weingart R

The FDA does not conduct clinical trials or attempt to discover new treatments, but rather requires companies or other entities to fund marketing approvals

9 The Caffeine for Apnoea of Prematurity (CAP) trial challenged this belief, finding that caffeine was associated with long-term neurodevelopmental benefits, despite ultrasonographic findings that types and frequency of brain injury were similar between groups