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The difference between the two is that cyanocobalamin is a synthetic form of Vitamin B12 found only in supplements (pills), while methylcobalamin is a naturally occurring form that you can get through either food sources or injections

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Hong G, et al

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15 A 2023 study found that patients with cognitive impairment who received active B12 (methylcobalamin + adenosylcobalamin) showed significant improvement in cognitive assessment scores after six months compared to controls

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Progress in Neurobiology 88 (3): 203220

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