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Reference standards: anastrozole, cabergoline, clomiphene citrate, letrozole, mesterolone, and raloxifene hydrochloride (EDQM, Strasbourg, France)

Germline and somatic mutations in METs kinase domain leading to constitutive activation are seen in renal papillary carcinoma, childhood hepatocellular carcinoma and colorectal cancer [10,11,12], whilst intronic mutations leading to an exon 14 deleted splice variant are seen in non-small cell lung cancer (NSCLC) [6]