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The glycosyltransferase MshA conjugates myo -inositol-1-P to UDP-GlcNAc and produces GlcNAc-Ins-P

A C9ORF72 mutation has been described as frontotemporal dementia-ALS 1 (FTDALS1), which is found in approximately 40% of patients with familial ALS and 3% of patients with sporadic ALS in Europe and the United States [22]