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Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence

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Cagrilintide + tirzepatide swaps semaglutide for tirzepatide, which adds GIP receptor activity

GroEL/GroES or DnaK/DnaJ/GrpE system) can actively assist in correct protein folding and protect misfolded proteins from aggregation, while proteases degrade stably misfolded and aggregated protein species via ATP-dependent mechanisms (recently reviewed in [14])