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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

For example, what if we want to know a value on the previous distribution that corresponds to the 90th percentile

This was highly evaluated by specialist provision and early years centres in supporting smooth transitions for children moving into Primary 1

To avoid undue variation, the lower and upper 0.5% of the intake measurements were excluded