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Through integrated cell-biological, biochemical, and structural analyses, we demonstrate that this gate-locking activity is both necessary and sufficient for cohesion maintenance, operates independently of Pds5 competition, and is tightly regulated during the cell cycle

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ROS-induced damage to important biomolecules is widely recognized as a significant mechanism contributing to the development of various chronic diseases (Valko et al., 2005[430])

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The distribution of these PUFA derivatives in specific membranes and vesicles will require further chemical analysis

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