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In addition, even though taking into account potential confounders is more important than the sample size by itself as aforementioned, our sample size may have limited the power to detect differences in patient-centered outcomes, particularly endoscopic remission. Several strengths have to be underlined such as the inclusion of consecutive patients with daily practice standardized evaluation and high-quality collected data anticipating the future use for real-world evidence research and methodological expertise in comparing real-world data [7,9,25]

Likewise, clinical trials evaluating antiviral or anti-inflammatory endpoints, such as viral load, disease outcomes, and cytokine biomarkers, are either preliminary or lacking and warrant further investigation

Shigamab comprises two antibodies against shigatoxin 1 and 2 (Stx1 and Stx2), which Shiga-toxin-secreting E

doi: 10.1016/S0009-2797(02)00070-4 155 MurrayIAPattersonADPerdewGH