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In particular, the integration of stable isotope tracing and MSI has proven to be highly beneficial for investigating metabolic activity in heterogeneous tissues 12 and spatially mapping the flux of fatty acid synthesis and elongation in gliomas and healthy brain tissue 13

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Finally, inflammation and endothelial activation leads to a pro-thrombotic phenotype due to the upregulation of components of the coagulation cascade including tissue factor (TF) (Sohn et al., 2005)