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Note that while elevated homocysteine is associated with an increased risk of Alzheimer's disease, systematic reviews of clinical trials comparing vitamin B12 supplementation to placebo groups have not shown a significant effect in preventing or slowing Alzheimer's disease or cognitive decline

GI changes (constipation or diarrhea) are more often linked to B12 deficiency or underlying gut conditions that also impair B12 absorption

The metabolite mixes used here were the same as the metabolites that correlated with the acute and sustained increases of FMD observed in humans

Some patients may experience slight redness or tenderness at the injection site