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Statements Author contributions EK: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review and editing

At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / omega-3 fatty acids (EPA + DHA), typically from fish oil or algae oil Primary interaction type / pharmacodynamic (lipid and platelet pathways), not pharmacokinetic Triglyceride effect / isotretinoin raises triglycerides in up to 44% of patients