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Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R

This terminology is applied based on either a visual inspection or a biopsy of the lesion

Long-term follow up is essential

Melanotan I (MT-1) is a linear peptide of 13 amino acids with the following sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH Molecular Formula: CHNO Molecular Weight: 1646.85 Da Its selective agonism of the melanocortin-1 receptor (MC1R) present on melanocytes induces eumelanin pigmentation, the photoprotective form of melanin