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In animal studies, sphingosine 1-phosphate preserved fertility in irradiated female mice without propagating genomic damage in offspring, suggesting it might have a role to reduce radiotherapy-induced sterility during clinical treatment (Paris et al, 2002)

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In the TME, ammonia secreted by cancer cells stimulates CAFs and subsequently triggers autophagy-related signals in CAFs

However, reliance on caffeine alone for weight management is not advisable, as long-term effects on weight and health require a balanced diet and regular physical activity