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There is insufficient clinical research to establish the safety or efficacy of these injections in pregnant women, so avoiding them is advised to prevent any possible risk to the developing fetus

Published literature includes over 100 studies examining its effects in various in-vitro and animal model systems, with research groups investigating gastrointestinal cytoprotection, tendon and ligament tissue models, and neurological signaling pathways

In 6 healthy male subjects given a single oral dose of [14C]palbociclib, a median of 91.6% of the total administered radioactive dose was recovered in 15 days