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10.1371/journal.pone.0069830 87 SantosR

This conservative approach allows for gradual cellular adaptation while minimizing the potential for excessive detoxification responses

Accordingly, unlike exogenous TNF alonewhich was unable to increase chromatin accessibility at the IL-6 locus and consequently to induce IL-6 gene expressionendogenously produced TNF increased histone acetylation as well as deposition of H3K4me1 at distal enhancer sites of the IL-6 locus