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Modification of lipid-based nanoparticles: an efficient delivery system for nucleic acid-based immunotherapy

have engineered a novel lipid-based nanoparticle, termed CDA-manganese particles (CMPs), that selectively localizes within tumor-resident innate immune cellsincluding DCs, macrophages, and MDSCsto drive robust immune activation and reprogram immunologically cold tumors into hot phenotypes [199]

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