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Disease resolution may take weeks to months Lupus erythematosus (figure 24) 10% of cases of LE-like reactions are drug-induced Chronology - usually months (even years) after the first exposure to the medication Autoantibodies - anti-Ro / La may be positive, and anti-histone antibodies can be found in 95% of cases of drug-induced lupus compared with 50% of cases of idiopathic lupus SCLE (subacute cutaneous lupus erythematosus) Is more likely to be drug-induced when the rash is widespread ie also involves the trunk and distal extremities Several medications have been implicated including PPI, calcium-channel blockers, thiazide diuretics, terbinafine, beta-blockers, ACE inhibitors, tamoxifen, leflunomide, acebutolol, some of the biologics, carbamazepine, cinnarizine, ticlopidine, naproxen, and gold With some drugs there can be a delay of several months to years before the rash presents

The matrices on which the fibroblasts are studied influence non-muscle myosin II activity

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Both in humans and in rats, IFN- modulates the pigmentation state of melanocytes, but in high concentrations limits melanocytes maturation and differentiation (You et al., 2013