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Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ

The majority of tumours develop acquired chemotherapy resistance, where an initially chemosensitive tumour adapts in response to chemotherapy through various mechanisms including: (i) increased cell viability which can be directly triggered by impaired apoptosis or increased proliferation [19], (ii) improved DNA repair [19], (iii) increased drug efflux and altered drug metabolism [19,20,21], (iv) propagation of cancer stem cells [22], (v) increased invasive potential [23] and (vi) increased tumour hypoxia with altered angiogenesis [24]

GLP-1s act on GLP-1 receptors