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In addition to the dose and route of administration, the adverse events may also be linked to the underlying physiological state, as PD participants on a 6000 mg/day dose of NAC reported worsening PD symptoms, whereas this dose was generally well-tolerated by the healthy group [36]

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[18] In shellfish, astaxanthin is almost exclusively concentrated in the shells, with only low amounts in the flesh itself, and most of it only becomes visible during cooking as the pigment separates from the denatured proteins that otherwise bind it