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This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

Gut-brain axis: role of lipids in the regulation of inflammation, pain and CNS diseases

BPC-157 has demonstrated excellent tolerability across numerous preclinical studies with no significant adverse effects even at high doses

For instance, the degree of immune cell infiltration and the activity of cancer-associated fibroblasts (CAFs) demonstrate significant variations among subtypes, which may potentially impact treatment efficacy and patient prognosis ( Therefore, understanding the clinical manifestations and biological characteristics of various subtypes is essential for developing effective treatment strategies