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Downregulation of PCBP1/2 mediates Fe 2+ release and induces ferroptosis To explore the potential mechanism by which ACE elevates Fe 2+ levels, iron metabolism proteins associated with ACE were screened by Western blot based on proteomic results (Fig

Finally, in the plant-rhizobium symbiosis, nitrogenase is protected by plant-produced leghemoglobin, a heme-containing O 2 scavenger that buffers O 2 to levels sufficient to support respiration, but not high enough to damage nitrogenase (Rutten & Poole, 2019)