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Oxidative stress, which arises when production of free radicals exceeds their neutralization, is a common complication of chronic inflammation and can have detrimental effects on the integrity of the BBB and further perpetuate inflammatory responses within the brain (Schreibelt et al., 2007

For apoptosis, PI3K/Akt is a key pathway, with the main members are phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt)

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According to the measurement results, we found that in contrast to the normal BHI control group, the GSH of L