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In mature spermatocytes, mtDNA molecules may increase in response to higher ATP demand, providing energy reserves for sperm motility [66, 67]

For example, second and third generation anaplastic lymphoma kinase inhibitors, brigatinib and lorlatinib, respectively, have also been unsuccessful in the treatment of primary brain tumors, despite achieving intracranial responses in the treatment of metastatic non-small cell lung cancer (124)

Segments S5, S6 and extracellular pore loops (P-loops) connecting S5 and S6 in each domain create the pore domain through which Na + ions pass, containing the selectivity filter

Tofersen is an ASO that reduces SOD1 protein synthesis by mediating the degradation of SOD1 mRNA