glutathione-6-dehydrogenase definition Anemia:- Part 10 Frontiers | Glucose-6-Phosphate Dehydrogenase Deficiency

Abbreviations ALD: Alcoholic liver disease BMDM: Bone marrow-derived macrophage BMP: Bone morphogenetic protein CDT: Carbohydrate-deficient transferrin C/EBP: CCAAT/enhancer-binding protein CP: Ceruloplasmin DAMPs: Damage-associated molecular patterns DcytB: Duodenal cytochrome b DMT1: Divalent metal transporter-1 EGF: Epidermal growth factor EPO: Erythropoietin ERFE: Erythroferrone FPN: Ferroportin GLUT4: Glucose transporter 4 GPX4: Glutathione peroxidase 4 GSH: Glutathione HCP1: Heme carrier protein-1 HIFs: Hypoxia-inducible factors HJV: Hemojuvelin HO1: Heme oxygenase 1 HSCs: Hepatic stellate cells HGF: Hepatocyte growth factor 4-HNE: 4-Hydroxy-2-nonenal IL6: Interleukin 6 IL1: Interleukin 1 IL22: Interleukin 22 IRE: Iron-responsive element IRPs: Iron regulatory proteins IRS1: Insulin receptor substrate 1 JAK2: Janus kinase 2 KCs: Kupffer cells LCN2: Lipocalin-2 LPS: Lipopolysaccharide NAC: N -Acetylcysteine NAFLD: Nonalcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis NF-B: Nuclear factor-B NLRP3: NOD-like receptor family pyrin domain containing 3 NRF2: Nuclear factor erythroid 2-related factor 2 PDGFR: Platelet-derived growth factor receptor ROS: Reactive oxygen species SIRT1: Sirtuin1 SMA: Smooth muscle -actin STAT3: Signal transducers and activators of transcription 3 TS: Transferrin saturation TfR: Transferrin receptor TNF: Tumor necrosis factor References Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J (2019) Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study

doi: 10.5539/gjhs.v6n6p144

Diabesity negatively affects transferrin saturation and iron status

Although the results of a Phase III clinical trial showed that using elesclomol to treat melanoma did not significantly benefit tumor patients, elesclomol had anti-tumor effects on patients with low plasma lactate dehydrogenase levels