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Key points Epidemiological data have suggested increased prevalence of benign thyroid disease with low selenium status, but the optimum range of intake is likely to be narrow, warranting a cautious approach to recommending selenium supplementation

Single nucleotide variations in the C13orf31 gene , resulting in amino acid changes in p.C284R and p.I254V in a protein of unidentified function, play a role in the development of systemic juvenile idiopathic arthritis and are associated with heightened susceptibility to leprosy and CD (66).This suggests that individuals with IBD may have an inherent vulnerability to mitochondrial dysfunction, particularly influenced by the gut environment

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